What is influenza and how is it caused?

Influenza, also known as the flu, is a viral infection that primarily affects the respiratory tract. Its symptoms include fever, runny nose, stuffed up nose, fatigue, headache, cough, sore throat, vomiting, diarrhea, and achy muscles and joints. Not only is the flu contagious, it could become severe and even prove to be fatal if left untreated.

The flu is largely caused by three types of viruses, that is the influenza virus A, B and C. Type A is responsible for the deadly influenza pandemics while type B causes less significant, more localized outbreaks. Meanwhile, type C is less common and causes only mild symptoms. Capable of passing from person to person by airborne transmission (i.e., sneezing or coughing), the virus is also known to survive on objects for a short period of time. Therefore, influenza can spread through touch too. Moreover, the influenza virus can also spread by inhaling droplets that have been coughed or sneezed out by an infected person or by coming in direct contact with an infected person’s secretions.

Is Tamiflu an effective antiviral drug for Bird Flu?

Tamiflu (Oseltamivir) the drug in use, blocks the influenza virus from spreading between the body cells. As a consequence, this antiviral drug is used in the treatment and prophylaxis of both Influenza virus A and B infections. Oseltamivir, a neuraminidase inhibitor, first and foremost acts as a transition-state analogue inhibitor of influenza neuraminidase, preventing progeny versions from becoming detached from infected cells.

The first orally active neuraminidase inhibitor to be commercially developed, Tamiflu (Oseltamivir), is a prodrug that is hydrolysed hepatically to active metabolites. Developed by US-based Gilead Sciences and currently being marketed by Hoffmann–La Roche (Roche) under the trade name Tamiflu, this drug is generally available by prescription only.

Why Tamiflu?

• It is recommended for use during infections with flu viruses A and B
• It eases various ailments like weakness, cough, headache, fever, sore throat that accompany the flu affliction
• It can prevent the onset of flu even when the patient has been exposed to the virus

Oseltamivir, a neuraminidase inhibitor, serves as an aggressive inhibitor for sialic acid that is found on the surface proteins of normal host cells; Tamiflu, in fact, prevents new viral particles from being released by infected cells.