Leptinal® is our premier cardiovascular and weight management support product.* Leptinal contains a potent array of heart-friendly nutrients, all in one softgel capsule. Our mercury-free DHA is the finest essential fatty acid available in the world and a proven nutrient for cardiovascular fitness.* A special extract of pomegranate delivers unparalleled protection for the circulatory system.* Plus, a unique combination of citrus-polyflavones and tocotrienols promote healthy cholesterol metabolism.*

The Power of Leptin

Leptin is a hormone that comes primarily from fat cells in white adipose tissue. It travels through the blood and enters the brain, wherein it regulates metabolic signals involved with energy production, cholesterol synthesis, thyroid function, liver function, pancreatic function, and bone formation. Leptin function is central to the weight management issue. In healthy metabolism there is a flow of leptin-dominant communication between white adipose tissue, the brain, the liver, and the pancreas.*

Just as muscles get out of shape, so does white adipose tissue. As fat cells bulge in size it reduces their ability to release stored fat. Once this happens white adipose tissue actually begins to generate stressful metabolic signals that add to the overall feeling of wear and tear. The flow of proper leptin-related communication may become disrupted, in turn causing metabolic stress and greater difficulty managing weight.The big question of the 21st century is: How fit is your fat? The Leptin Diet book explains how to eat to be in harmony with leptin, vital information for healthy weight management.*

Weight Management

Leptinal® is the first product specifically designed to help turn off the metabolically disrupting stress actually coming out of fat cells.* It also helps promote normal fat cell function, assisting normal fat metabolism.* DHA helps turn down the excess production of leptin, while at the same time turning on a metabolic signal in stored fat that helps to break down the stored fat (uncoupling protein 2 -UCP2).* DHA also helps turn on a key gene signal in muscle (uncoupling protein 3 - UCP3) that helps muscles burn fat for fuel, which is assisted by actually using muscles (exercise).* The Punicalagins of pomegranate are a nutritional tool the body may use to naturally regulate stressful cellular signals.* Too much cellular stress interferes with metabolic signals needed for healthy metabolism.* Leptinal® is a powerful tool in the fight to maintain healthy metabolic function.*

Supporting Thyroid Function

Leptinal® supports the function of thyroid hormone in several ways.* By helping to promote natural leptin balance the brain senses nutritional adequacy, in turn permitting metabolism to run at a more normal pace.* Proper entry of leptin into the brain is critical for the initial brain signals that activate the production of thyroid hormone. Too many triglycerides in the blood may interfere with normal leptin entry into the brain. Nutrients like DHA and Styrinol help to promote healthy triglyceride levels, in turn supporting the normal process of leptin entry into the brain.*

Additionally, the important activation of thyroid hormone occurs on the cell membranes in the liver. DHA and GLA will build themselves into cell membranes over time, as do the tocotrienols that help to protect cell membranes.* Thus, Leptinal® enhances the structural integrity of cell membranes, including liver cell membranes, thereby facilitating normal activation of thyroid hormone.* DHA and thyroid hormone act synergistically inside cells to turn on important genes that support natural fat burning (sterol regulatory element binding proteins).*

Healthy Bones and Nerves

DHA accumulates in bones and is vital for the healthy structure and function of bones.* Tocotrienols have been shown to promote healthy bone formation.* It is important to support bone health on any weight management program.*

DHA is a preferred fatty acid for use in the formation of nerve cells, promoting the natural electrical function of these important cells.*

Protecting brain cells is also important. This is because nerve cells do not split and divide like other cells, they must be repaired whenever possible. The alpha tocotrienol form of vitamin E is easily taken up in nerve cell membranes where it acts as a potent antioxidant to protect nerve cells.* Animal studies on pomegranate also show its antioxidant activity is highly protective to the nervous system.*

Blood Pressure

Leptinal® offers the finest essential fatty acids available on the market today. The DHA used in our product is molecularly distilled marine lipid oil, free of all impurities such as mercury or other contaminants often present in fish. It is specially modified to be high in DHA, the most important cardiovascular system omega 3 essential fatty acid.*

DHA is a preferred oil for the structure of cell membranes that comprise the arteries and overall lining of the circulatory system, contributing to proper structural integrity of arterial walls.* DHA in these cell membranes helps to maintain natural flexibility of the circulatory structure that in turn enhances the normal flow of blood through the circulation.* DHA has been shown to support healthy heart function.* GLA is the most important omega 6 essential fatty acid, also helping to build healthy cell membranes, including those cells lining the walls of arteries.*

Prostaglandins are regulatory signals generated from the fatty acid components of cell membranes. They perform a variety of vital functions in normal metabolism as well as under conditions of stress, making them incredibly important to health. One friendly prostaglandin is called PGE3, which is supported by DHA supplementation.* The other friendly prostaglandin is called PGE1, which is supported by GLA supplementation.* Prostaglandin regulation has a large bearing on maintaining healthy blood pressure, as these signals are used by cells lining artery walls to facilitate proper circulation and are involved in the normal fluctuations of blood pressure (systolic and diastolic). The synergistic balance of DHA and GLA are fundamental nutrition for healthy artery function and maintenance of normal blood pressure that is already in the normal range.* Since DHA and GLA are generally lacking in the American diet, supplementation is a convenient way to boost dietary intake.*

Our pomegranate extract contains the antioxidant power of the punicalagins found only in pomegranate.* This important antioxidant is degraded in juice products and lost almost entirely by pasteurization. In Leptinal®, it is preserved and standardized, wherein it helps to maintain healthy circulation and protect the cardiovascular system from free radicals.* Tocotrienols are also protective to the lining of the circulatory system, helping to promote normal and healthy function.*

Healthy Cholesterol Levels

Maintaining healthy cholesterol levels, naturally, is fundamental to cardiovascular health. This requires eating a proper diet, watching the amount of fat and refined sugar intake, and exercise. There are no shortcuts. Nutrients in Leptinal® are synergistic with a healthy diet and lifestyle, towards the goal of maintaining healthy cholesterol that is already in the normal range.*

SytrinolTM contains citrus-derived compounds known as polymethoxylated flavones (tangeretin and nobiletin). angeretin has been shown to support healthy levels of LDL cholesterol by modulating the production of apoprotein B (apo-B) and triglycerides, key factors that are required to produce LDL.* SytrinolTM has been tested in three human clinical trials and has been shown to be supportive of healthy cholesterol levels, including the important HDL levels.* In softgels containing DHA and tocotrienols SytrinolTM is four times better absorbed than in a plain powder capsule.*

Rounding out the Leptinal® formula are two sources of tocotrienols, a palm fruit extract contained in SytrinolTM and rice bran oil concentrate rich in alpha and gamma tocotrienol.* Alpha tocotrienol is a potent antioxidant form of vitamin E, helping to protect circulation and nerves.* Gamma tocotrienol helps to maintain healthy cholesterol levels already in the normal range.*

Additionally, GLA and DHA have been shown to support the formation of HDL cholesterol and overall healthy metabolism of cholesterol and triglycerides.* A variety of studies show that pomegranate supports healthy cholesterol levels.*

The FDA allows the following claim: Supportive but not conclusive research shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary heart disease.

Leptinal®'s powerful combination of synergistic nutrients makes it the first choice for nutritional support for healthy cholesterol metabolism.*

SytrinolTM is a trademark of SourceOne Global Partners. Leptinal® is a registered trademark of Wellness Resources, Inc.