Phytochemicals: 15 Health Benefits of Limonoids

1. limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis." by Harish Kumar G, Vidya Priyadarsini R, Vinothini G, Vidjaya Letchoumy P, Nagini S.2. Leukemia cells
In a study of " Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem). by Kikuchi T, Ishii K, Noto T, Takahashi A, Tabata K, Suzuki T, Akihisa T.3. Aedes albopictus (limonoids against Aedes albopictus." by Hafeez F, Akram W, Shaalan EA (Source from Department of Agricultural Entomology, University of Agriculture, Faisalabad, Pakistan.) posted in PubMed, researchers found that The oils from Minneola and Chinese lime did not contain limonin and nomilin, and were therefore weak in terms of LC(50) values. Presence of limonin and nomilin in plant products is therefore a significant indicator of the pest control that needs to be exploited in other plants as well.

limonoids from the seeds of Azadirachta indicia A. Juss. (neem)." by Akihisa T, Noto T, Takahashi A, Fujita Y, Banno N, Tokuda H, Koike K, Suzuki T, Yasukawa K, Kimura Y.5. Detoxification
In a study of " Limonin methoxylation influences the induction of glutathione S-transferase and quinone reductase." byPerez JL, Jayaprakasha GK, Valdivia V, Munoz D, Dandekar DV, Ahmad H, Patil BS.6. (Source from Vegetable and Fruit Improvement Center, Department of Horticultural Sciences, Texas A&M University, College Station, TX 77845-2119, USA.) posted in PubMed, researchers found that additive activity of proliferation inhibition and activation of caspase-3 by limonoids was observed when combined with camptothecin, demonstrating the induction of apoptosis and concluded that both limonoids induced apoptosis by activation of intrinsic apoptosis pathway and activation of p21 leading to arresting cells at G2/M phase of the cell cycle.

(Source from Program in Integrative Nutrition and Complex Diseases, Texas A&M University, College Station, TX 77843, USA.) posted in PubMed, researchers found that dietary combination with FO enhanced the suppressive effects (P < 0.05) of Cur or Lim with respect to CD4(+) T-cell proliferation in response to anti-CD3/28 mAb. These results suggest that combination chemotherapy (FO+Cur or Lim) may favorably modulate CD4(+) T-cell-mediated inflammation.

limonoids from Swietenia mahagoni against multiple-drug-resistant (MDR) bacterial strains." by Rahman AK, Chowdhury AK, Ali HA, Raihan SZ, Ali MS, Nahar L, Sarker SD.9. Anti-inflammatory and analgesic activities
In a study of "Anti-inflammatory and analgesic activities of ethanolic extract and two limonoids from Melia toosendan fruit." by Xie F, Zhang M, Zhang CF, Wang ZT, Yu BY, Kou JP.10. Antioxidant activity
In a study of " Red Mexican grapefruit: a novel source for bioactive limonoids and their antioxidant activity." by Mandadi KK, Jayaprakasha GK, Bhat NG, Patil BS.11. Plasmodium falciparum
In a study of " Antimalarial tetranortriterpenoids from the seeds of Lansium domesticum Corr." by Saewan N, Sutherland JD, Chantrapromma K.12. Gender differences
In a study of " Gender differences in limonin pharmacokinetics in rats." by Liang Y, Xie L, Liu XD, Hu YZ, Lu T, Wang GJ.13. Neuroblastoma
In a study of " Citrus limonoids induce apoptosis in human neuroblastoma cells and have radical scavenging activity." by Poulose SM, Harris ED, Patil BS.14. Antifungal activity
in a study of " Antifungal activity of limonoids from Khaya ivorensis." by Abdelgaleil SA, Hashinaga F, Nakatani M.15. Anti-HIV-1
In a study of " Anti-HIV-1 limonoid: first isolation from Clausena excavata." by Sunthitikawinsakul A, Kongkathip N, Kongkathip B, Phonnakhu S, Daly JW, Spande TF, Nimit Y, Napaswat C, Kasisit J, Yoosook C.16. Etc.