The World Most Popular Herbs - Ashwagandha Health Benefits and Side Effects

Withania
Health Benefits
1. Alzheimer's disease
Withanamidesm, the ingredient in Ashwagandha have demonstrated the property of binding to the active motif of beta-amyloid (25-35) of which can cause the irreversible neurodegenerative disorder of Alzheimer's disease with symptoms of confusion, memory loss, and mood swings, according to the study of "Withania somniferaAlzheimer's disease" by Jayaprakasam B, Padmanabhan K, Nair MG., posted in PubMed(2).

2. Oxidative Stress in cognitive and other neurodegenerative disorders
Dried root aqueous extracted from Ashwagandha has demonstrated the property of by enhancing the PC12 cells against both H(2)O(2)- and Aβ((1-42))-induced cytotoxicity that can prevent the devlopment of cognitive and other neurodegenerative disorders, according to the study of "Withania somnifera
HPV and Cervical cancer
HPV is considered as the main cause of cervical cancer as it can suppress tumor suppressor proteins p53 and pRb. Withaferin A (WA) in Ashwagandha has demonstrated the activity of reactivation of tumor suppressor pathways and cause apoptosis in cervical cancer cells, according to the study of " Munagala R, Kausar H, Munjal C, Gupta RC., posted in PubMed(5).


"In Vitro Anticancer Activity of the Root, Stem and Leaves of against Various Human Cancer Cell Lines" by Yadav B, Bajaj A, Saxena M, Saxena AK., posted in PubMed(7).

8. Immunostimulatory effects
Ashwagandha can enhances immune function by increasing immunoglobulin production and regulating antibody production by augmenting both Th1 and Th2 cytokine production, according to the study of "Ashwagandha
Withania
"Recent studies on aphrodisiac herbs for the management of male sexual dysfunction--a review" by Malviya N, Jain S, Gupta VB, Vyas.S. posted in PubMed(11)

Withania 3. It may cause slight drowsiness to certain people
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